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Explore BrainCase’s latest viral tools and genetic sensors, enabling safer, more precise CAR-T/TCR-T cell research.
Engineered CAR-T cells have recently made breakthroughs in treating hematologic malignancies. However, commonly used γ-retroviruses and lentiviral vectors integrate randomly into the genome, causing functional heterogeneity, gene silencing, and even potential oncogenic risks, limiting efficacy and safety.
Ark313, developed from AAV6 variants, supports non-nucleoside DNA delivery, CRISPR-Cas9 knockouts, and precise large-fragment gene integration. It efficiently transduces mouse T cells, enabling the development of safer, more precise CAR-T and TCR-T cells, and offering new possibilities for cellular therapy and T cell immunity research.
We offer Ark313 serotype packaging services, tailored to your experimental needs.
Figure 1. Ark313 can achieve effective gene targeting in primary mouse T cells (Eyquem et al, 2023)
Developer: Miao Jing Lab, Beijing Institute for Brain Research
Highlights: High-resolution fluorescent sensor for in vivo CXCL10 dynamics.
Applications: Mapping CXCL10-mediated immune responses and spatiotemporal signaling in inflammation and brain disease models.
| Product Number | Product Name |
|---|---|
| BC-5217 | rAAV-CMV-LoX3-1.0-P2A-mCherry |
| BC-5218 | rAAV-CMV-LoX3-mut-P2A-mCherry |
Developer: Kiryl Piatkevich Lab, Westlake University
Highlights: Red fluorescence, soma-targeted, broad dynamic range, high signal-to-noise ratio, comparable to green GECIs.
Applications: In vivo multimodal neuronal imaging.
Figure 2. Expression and characterization of jRGECO1a, FRCaMPi, and SomaFRCaMPi in zebrafish neurons (Piatkevich et al, 2025)
| Product Number | Product Name |
|---|---|
| BC-4182 | rAAV-hSyn-NES-SomaFRCaMPi |
| BC-4184 | rAAV-hSyn-NES-FRCaMPi |
| BC-4183 | rAAV-CAG-DIO-NES-SomaFRCaMPi |
| BC-4389 | rAAV-hSyn-DIO-NES-SomaFRCaMPi |
| BC-4390 | rAAV-hSyn-DIO-NES-FRCaMPi |
Developer: Zhifei Fu Lab, Fujian Medical University
Highlights: High thermal stability and resistance to EM sample processing; enables high-SNR subcellular imaging and rapid whole-brain clearing.
Applications: Subcellular imaging and brain atlas mapping.
| Product Number | Product Name |
|---|---|
| BC-3987 | rAAV-CAG-mYongHong |
| BC-3997 | rAAV-cFos-mYongHong |
| BC-3782 | rAAV-CAG-DIO-mYongHong |
| BC-3412 | rAAV-EF1α-DIO-mYongHong |
| BC-3415 | rAAV-EF1α-FDIO-mYongHong |
| BC-SL055 | NCSP-mYH-2E5 (Sparse Labeling) |
Developer: Fuqiang Xu Lab & BrainCase
Highlights: Capsid variants enhance exogenous gene expression; allows high-brightness sparse labeling of neurons.
Applications: Gene delivery in small/large brain nuclei and neuronal fine-structure analysis.
Figure 3. Efficient In Situ Transduction of the Primary Somatosensory Cortex by AAV13 Mutants (Xu and Lin, 2024)
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