Features: The chemokine CXCL10 is one of the key signaling molecules mediating cell migration during development and immune responses. It specifically recruits effector cells for directional migration and regulates their activation, proliferation, and survival, demonstrating high functional complexity and specificity.
The genetically encoded fluorescent probe GRAB-LoX3-1.0 features a high signal-to-noise ratio, nanomolar affinity, millisecond temporal resolution, and submicron spatial resolution, enabling the first high-precision visualization of dynamic changes in CXCL10. This sensor provides a novel tool and theoretical basis for elucidating chemokine functions and immune information transmission under inflammatory conditions.
