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This study identifies a non-spinal bladder–brain vagal pathway that transmits inflammatory signals and maintains bladder homeostasis, revealed by viral tracing , DREADD-fMRI and Immunohistochemistry.
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Features ： A recombinant AAV designed for microglia-specific chemogenetic inhibition. The mIba1 promoter enables selective expression in microglia. Four miR-9 target sites reduce off-target neuronal expression. Application: Microglia labeling Promot
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Features ： A recombinant AAV vector for microglia-specific fluorescent labeling. The mIba1 promoter enables selective expression in microglia. Four miR-9 target sites reduce off-target neuronal expression. Application: Microglia labeling Promoter: m
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Features：A recombinant AAV designed for microglia-specific chemogenetic inhibition. The mIba1 promoter enables selective expression in microglia. The inhibitory DREADD receptor miniDi suppresses cell activity upon activation by CNO or DCZ, depending
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Features： A modified variant of the glycine receptor (GlyR) that incorporates the pharmacological properties of PSAM for chemogenetic regulation. It is composed of GlyR subunits with PSAM4-specific mutations introduced, enabling specific binding to
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A comprehensive comparison of AAV and lentiviral vectors, covering gene delivery mechanisms, packaging capacity, immunogenicity, and in vivo vs in vitro applications, with case studies from gene therapy, neuroscience, and cancer research.
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A Nature Communications study reveals a dual nose–brain axis in mice, showing how spoiled food odors activate distinct neural circuits to drive retching-like behavior and aversion.
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PRV is used to study the brain-wide retrograd multisynaptic input network structure of specific regions, neural network changes during neurodevelopment, communication pathways between peripheral organs and the central nervous system......
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Gut microbiota from bipolar disorder patients disrupts the VTA–mPFC dopamine pathway, impairing synaptic plasticity and inducing depression-like behaviors.
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Features ： ElectraOFF: Highly photostable negative-going green fluorescent voltage indicator for ultra-long neuronal recordings. Key Performance: 1) Negative polarity (fluorescence decreases with depolarization); 2) 6-fold improved photostability co
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