
Features: A recombinant AAV designed for microglia-specific chemogenetic inhibition. The mIba1 promoter enables selective expression in microglia. The inhibitory DREADD receptor miniDi suppresses cell activity upon activation by CNO or DCZ, depending on the experimental animal species. Four miR-9 target sites reduce off-target neuronal expression.
Application: Chemogenetics (microglia modulation)
Promoter: mIba1
Gene/Insert name:miniDi-P2A-mCherry
Tag/Fusion protein:mCherry
Titer:>1x10^13 VG/mL,>5x10^12 VG/mL
Volume:100μL
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