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Literature Insight | Nature Methods | A “Magic Tool” for Real-Time Observation of Synaptic Structural Dynamics — SynapShot

Literature Insight | Nature Methods | A “Magic Tool” for Real-Time Observation of Synaptic Structural Dynamics — SynapShot

The researchers developed a reversible fluorescent protein system—SynapShot—based on a dimerization-dependent fluorescent protein (ddFP) strategy.

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Xiaobu interprets a new strategy for effective treatment of spinal cord injury - knocking down polypyrimidine tract binding protein (PTB)

Xiaobu interprets a new strategy for effective treatment of spinal cord injury - knocking down polypyrimidine tract binding protein (PTB)

Spinal cord injury (SCI) is a serious disease of the central nervous system. After spinal cord injury, a large number of motor neurons are lost at the injury site, while astrocytes proliferate reactively and form dense glial scars. Modulating the density

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Xiaobu’s Interpretation | Neuron The thermoreceptor TRPC4 of hypothalamic heat-sensitive neurons—an important target for body temperature regulation

Xiaobu’s Interpretation | Neuron The thermoreceptor TRPC4 of hypothalamic heat-sensitive neurons—an important target for body temperature regulation

The stability of body temperature is a necessary condition for mammals to maintain life activities. Abnormal body temperature often indicates obvious disease changes in living organisms. The preoptic area (POA) of the hypothalamus is the bodys temperature

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Xiaobu’s interpretation | The new variant AAV.cc47 is here, achieving high efficiency and cross-species compatibility

Xiaobu’s interpretation | The new variant AAV.cc47 is here, achieving high efficiency and cross-species compatibility

AAV is one of the most commonly used viral vectors in the field of gene therapy. In recent years, AAV gene therapy has made progress in a variety of indications, including rare eye diseases, hemophilia, rare muscle diseases, central nervous system disease

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